Mike Godfrey was 19 when he found out he had H.I.V.
He was 29 when he began antiretroviral therapy.
He was 43 when he had a heart attack.
ãI felt fluttery,ä he said. ãWeird and fluttery. It went away. I ignored it. A week later, it came back, and this time I felt something in my arm too. I was too stupid to call an ambulance. I got in a cab and went to the hospital.ä
Mr. Godfreyâs experience exemplifies something a few AIDS specialists have long suspected, and cardiologists have now found evidence to support: People infected with H.I.V. have more heart attacks and have them earlier in life. Even patients whose infection is well suppressed by AIDS drugs are at higher risk.
Experts in the field said doctors need to be better informed about this little-known threat to their H.I.V.-positive patients. The threat also reinforces a message that public health experts keep emphasizing: H.I.V. is no longer an automatic death sentence, but it is still a dangerous disease.
ãI think most cardiologists and most H.I.V. specialists are not really aware of this,ä said Dr. Priscilla Y. Hsue, a cardiologist at San Francisco General Hospital who treats many AIDS patients. ãMost of the people I see are referred to me after theyâve had a heart attack, a bypass, a stent. To me, thatâs too late. We should be screening people for coronary disease, aggressively treating blood pressure, aggressively treating cholesterol.ä
People with H.I.V. have more than four times the risk of sudden heart attack as their uninfected peers, Dr. Hsue and her colleagues reported last month in The Journal of the American College of Cardiology.
The most likely explanation is that both the virus and the drugs that fight it cause chronic inflammation, said Dr. Paul M. Ridker, a Harvard Medical School professor who led pioneering studies that established the connection between inflammation and heart disease. (He was not involved in the study published last month.) Also, he said, the drugs cause the liver to make more cholesterol, another heart attack risk factor.
While the link between H.I.V. and heart disease is not generally known in the medical profession, some doctors who specialize in the treatment of AIDS patients have long suspected such a connection.
ãIâve had a number of patients ÷ men in their late 40s and early 50s ÷ who were just found dead at home,ä said Dr. Steven G. Deeks, an AIDS expert at the University of California, San Francisco, who was not involved in the study. ãIâve always thought that was happening more than it should.ä
Both the virus that causes AIDS and other infections that can accompany it can inflame tissues, he said. Inflammation can produce blood clots, which can cause heart attacks. And in the intestines, the virus can cause ãleaky gut syndrome,ä by which other inflammatory microbes enter the bloodstream.
Dr. Zian H. Tseng, a heart rhythm specialist and a co-author with Dr. Hsue of the new study, said he stumbled on the H.I.V.-cardiac connection while he was doing a survey of every sudden heart attack death in San Francisco and noticed that many victims were taking antiretroviral drugs.
ãInitially, I thought it was just because of the high prevalence of H.I.V.-positive people in San Francisco, but it was clearly more than that,ä he said.
The researchers scoured the medical records of 2,860 patients who were seen between 2000 and 2009 in Ward 86, San Francisco Generalâs famous AIDS clinic. For those who had died, they checked death certificates and paramedic reports and interviewed doctors and family members, trying to see how many had had heart attacks.
They acknowledged some limitations: Smoking and recreational drug use are more common among people with H.I.V., and few of the dead were autopsied. But all deaths that looked like overdoses, suicides or assaults, as well as slow AIDS deaths, were excluded.
There have been previous studies suggesting that people with H.I.V. develop high cholesterol and blocked arteries about a decade earlier than normal, but that is only now becoming widely recognized.
ãI didnât know I had a heart problem until I had a heart attack and a double bypass in 2003,ä said Mark Abramson, 59, author of the ãBeach Readingä series of gay mystery/romance novels.
Although he saw doctors and was intermittently taking AIDS medication when he had medical insurance during his years as a bartender, ãno one told me I was in a high-risk group.ä
He smoked and knew his blood pressure was ãa little high.ä He did not remember any cholesterol tests.
Sharon Hampton, 57, had heart trouble first and only later learned of a likely connection to the virus.
In her 30s, she developed high blood pressure and signs of congestive heart failure. A self-professed workaholic, she blamed the pressure of her job as a hospital claims processor. Her physician advised her to find something less stressful; she did for a while, but then moved to Sacramento and started working at another hospital.
At age 45, she said, ãI had a heart attack right at my desk ÷ thank God the E.R. was only seven feet away from the business office.ä
After a quintuple bypass, she initially went back to work. But her health deteriorated, and she has lived with family members since.
Last Thanksgiving, after a health crisis hospitalized her, she learned she had H.I.V.
ãI couldnât believe it,ä she said. ãI totally freaked out. I thought it had to be a false positive. Iâve been celibate for a long time. I never had that lifestyle. Iâm afraid of drugs.ä
But when she was young, she said, she was briefly married to a man she later learned injected drugs.
ãI just never knew,ä she said. ãHe was Michelangeloâs David. I was a country bumpkin.ä
She is apparently a rare ãelite suppressor,ä part of the 1 to 2 percent of the infected who, for unknown reasons, control the virus without drugs. Although she has a nearly undetectable viral load and no opportunistic infections, her doctors at U.C.S.F. believe that the virus contributed to her heart problems.
Jose Raneda, a 48-year-old former lawyer from Milwaukee, has seen the thinking about the H.I.V.-heart connection change in the last few years.
He has known he was infected since he was 21, started on AIDS cocktails as soon as they were available, never had a low CD4-cell count or an AIDS-related infection, and has always been slim.
But he had his first of two heart attacks at age 40.
ãI asked my H.I.V. doctor if it was related, and he said it wasnât,ä he said. ãI think he was mistaken.ä
His former physician, Dr. Ian H. Gilson of the Medical College of Wisconsin, agreed.
ãAt the time, we didnât have a lot of solid evidence of the connection,ä he said. ãMy thinking has evolved. Iâd tell him something different now.ä